Efficacy and Safety of Spironolactone Versus Bicalutamide in Female Pattern Hair Loss: A Retrospective Comparative Study

    Ayushi Jha, Md Zeeshan, Anupama Singh, Anupama Singh
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    TLDR Bicalutamide is more effective and safer than spironolactone for treating female hair loss.
    This retrospective study compared the efficacy and safety of spironolactone and bicalutamide in treating female pattern hair loss (FPHL) in 120 women aged 18-50. Patients were divided into two groups: one taking 100 mg of spironolactone daily and the other taking 50 mg of bicalutamide daily, both with topical minoxidil 2%. After 24 weeks, the bicalutamide group showed a significantly greater reduction in hair loss severity (28.20%) compared to the spironolactone group (19.51%). Global photographic assessments also indicated more marked improvement in the bicalutamide group. Despite the study's retrospective nature and small sample size, bicalutamide demonstrated greater efficacy and a better safety profile than spironolactone for FPHL treatment.
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