Ameliorative Effect of Tranexamic Acid on Physiological Skin Aging and Its Sex Difference in Mice
May 2019
in “
Archives of dermatological research
”
New to Hyaluronic Acid? There is a guide in the encyclopedia. Read the guide → Studysummary In a study using hairless mice, tranexamic acid was found to ameliorate natural skin aging, with stronger effects observed in female mice compared to males.
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The study on hairless mice over 2 years found that tranexamic acid (12 mg/kg/day, three times a week) reduced signs of skin aging by inhibiting plasmin synthesis, increasing hyaluronic acid production, boosting epidermal cell numbers, and suppressing matrix metalloproteinase (MMP) activity, thus preserving the extracellular matrix (ECM). The effects were more pronounced in female mice, indicating a sex difference in the ameliorative effects of tranexamic acid on skin aging.
