Ameliorative Effect of Tranexamic Acid on Physiological Skin Aging and Its Sex Difference in Mice

    May 2019 in “ Archives of dermatological research ”
    Keiichi Hiramoto, Yurika Yamate, Daijiro Sugiyama, Kazunari Matsuda, Yasutaka Iizuka, Tomohiko Yamaguchi
    TLDR Tranexamic acid reduces skin aging more in female mice.
    The study on hairless mice over 2 years found that tranexamic acid (12 mg/kg/day, three times a week) reduced signs of skin aging by inhibiting plasmin synthesis, increasing hyaluronic acid production, boosting epidermal cell numbers, and suppressing matrix metalloproteinase (MMP) activity, thus preserving the extracellular matrix (ECM). The effects were more pronounced in female mice, indicating a sex difference in the ameliorative effects of tranexamic acid on skin aging.
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