The Effect of Mesenchymal Stem Cell-Conditioned Medium Gel on Burn Wound Healing in Rats

    April 2022 in “ Veterinary world/Veterinary World ”
    Dian Ratih Laksmitawati, Siti Umrah Noor, Yati Sumiyati, Adrian Hartanto, Wahyu Widowati, Diah Kartika Pratami
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    TLDR The mesenchymal stem cell-conditioned medium gel improved burn healing and hair growth in rats better than other treatments.
    This study investigated the effects of mesenchymal stem cell-conditioned medium (CM) gel on the healing of third-degree burns in rats. Twenty-four Sprague-Dawley rats with dorsal burn wounds were divided into four groups: one treated with CM gel, one with placebo gel, one with silver sulfadiazine (SSD) cream, and one without treatment, over a 21-day period. The study assessed wound healing through indicators such as wound diameter, scab and blister formation, and hair growth. Post-treatment analysis of the skin involved histological staining to evaluate neutrophil and mononuclear cell infiltration, neovascularization, collagen area, and re-epithelization ratio. The results showed that the CM gel group experienced better wound healing and faster hair growth compared to the other groups.
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