Discoid Lupus Erythematosus Exacerbated by Contact Dermatitis Caused by Use of Squaric Acid Dibutylester for Topical Immunotherapy in a Patient with Alopecia Areata

    March 2008 in “ The Journal of Dermatology
    Yayoi Shimaoka, Atsushi Hatamochi, Yoichiro Hamasaki, Hiromi Suzuki, Hideyuki Ikeda, Soji Yamazaki
    TLDR Topical squaric acid dibutylester worsened discoid lupus erythematosus in a patient.
    A 57-year-old Japanese male with an 18-year history of discoid lupus erythematosus (DLE) developed alopecia areata and was treated with topical immunotherapy using squaric acid dibutylester (SADBE). After initial sensitization with 2% SADBE and subsequent low-concentration re-exposure to induce contact dermatitis on the scalp, the patient developed multiple red scaly lesions on his scalp and face within 2 months. These lesions were diagnosed as DLE, indicating that the contact dermatitis exacerbated his DLE. This case highlighted that DLE can be exacerbated by contact dermatitis, a rare occurrence with only two previously reported cases.
    Discuss this study in the Community →

    Research cited in this study

    1 / 1 results

    Related Community Posts Join

    6 / 131 results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  830 upvotes 1 year ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Anyone in the discord server for pp405 research?

      in Chat  5 upvotes 1 week ago
      The conversation is about users trying to regain access to a Discord server related to pp405 research, with differing opinions on the effectiveness of pp405 for hair loss. Specific treatments like Minoxidil, finasteride, and RU58841 are not mentioned in the conversation.

      community HMI 115 Phase 2 - Leaked pics from Discord

      in Research/Science  362 upvotes 1 year ago
      The conversation discusses HMI 115, a new hair loss treatment with promising results, showing a significant increase in hair density after two months. Some users are skeptical, while others are hopeful for its release and potential affordability.

    Related Research

    4 / 4 results