The Circulating Dihydrotestosterone/Testosterone Ratio Is Increased by Gut Microbial 5α-Reductase Activity in Females

    October 2025 in “ EBioMedicine ”
    Claes Ohlsson, Lei Li, Karin Horkeby … Louise Grahnemo
    Studysummary Women have a higher DHT/testosterone ratio than men, possibly due to gut bacteria activity.
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    Research cited in this study 3

    1. Circulating Androgen Regulation by Androgen-Catabolizing Gut Bacteria in Male Mouse Gut Gut Microbes · 2023
    2. Basics of Androgen Synthesis and Action Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism · 2022
    3. The Biochemical and Phenotypic Characterization of Females Homozygous for 5 Alpha-Reductase-2 Deficiency The Journal of Clinical Endocrinology & Metabolism · 1995