Comparative Analysis of the Cutaneous Microbiome in Psoriasis Patients and Healthy Individuals: Insights into Microbial Dysbiosis

The study compared the skin microbiome of 20 psoriasis patients with 13 healthy individuals, revealing significant microbial dysbiosis in psoriasis patients. Key findings include lower microbial diversity in psoriasis lesions, with a predominance of bacteria like Staphylococcus epidermidis and Staphylococcus aureus, while healthy individuals had more Actinobacteria spp. and Cutibacterium spp. Factors such as gender, age, and living environment influenced microbiome composition, with urban residents showing greater bacterial diversity. The study suggests that microbial dysbiosis may contribute to psoriasis pathogenesis and highlights the potential for targeting the skin microbiome in therapeutic strategies, though larger studies are needed for further understanding.