The document described a rare case of ectopic ACTH secretion (EAS) due to a primary lung neuroendocrine tumor (NET) in a 30-year-old female, presenting with symptoms like fatigue, muscle weakness, and hair loss. Despite normal vital signs, tests revealed elevated cortisol and ACTH levels, confirming EAS. A chest X-ray identified lung masses, avoiding the need for invasive inferior petrosal sinus sampling (IPSS). A biopsy confirmed a well-differentiated NET, and post-surgical treatment led to normalization of ACTH, blood glucose, and cortisol levels. The case highlighted that EAS should be suspected if a pituitary adenoma is not visible on MRI, and a simple chest X-ray can be a useful diagnostic tool. The patient remained asymptomatic at a 6-month follow-up.
3 citations
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June 2018 in “The New England Journal of Medicine” A woman with Cushing's syndrome improved after surgery to remove a tumor causing the condition.
April 2020 in “Journal of the Endocrine Society” Non-classic congenital adrenal hyperplasia (NCCAH) can mimic PCOS and requires genetic testing for proper diagnosis and treatment.
27 citations
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December 2013 in “Endocrinology” Researchers created a mouse model for Cushing's syndrome to study glucocorticoid excess and potential treatments.
7 citations
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October 2012 in “S. Karger AG eBooks” Some conditions mimic PCOS symptoms and need careful diagnosis to treat potentially serious health issues.
April 2023 in “Clinical Chemistry and Laboratory Medicine” The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.
