SAT-127 Localization and Treatment of the Ectopic ACTH Syndrome Using Somatostatin Analogues

Ectopic ACTH syndrome (EAS) is a rare disorder characterized by severe hypercortisolism, often due to tumors with somatostatin (SS) receptors. This case study involved a 49-year-old female with EAS, presenting with severe Cushingoid features and high plasma ACTH levels. A gallium-68 dotatate PET/CT scan identified a neuroendocrine lung tumor as the source of ectopic ACTH. Treatment with Sandostatin LAR, an SS analogue, over 12 weeks led to significant clinical and biochemical improvements, including reduced serum cortisol levels and controlled hypertension. This case highlighted the effectiveness of SS analogues in localizing and treating EAS when surgical intervention was not feasible.