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In this case study, a 12-year-old boy with Cushing's Disease experienced a complex diagnostic journey; ultimately, a left-side ACTH-secreting microadenoma was identified and treated with gamma knife therapy, normalizing hypercortisolism but resulting in growth hormone deficiency.

This case study reports a rare instance of ectopic ACTH secretion from a primary lung neuroendocrine tumor in a young woman, highlighting successful diagnosis and treatment following symptoms of Cushing syndrome, with normalization of ACTH, glucose, and cortisol levels post-surgery.

This study systematically compared pediatric and adult Cushing's disease patients, revealing more severe and earlier-onset symptoms in males, and distinct gender-specific clinical manifestations.

This case report details a 13-year-old boy with Cushing syndrome, where BIPSS identified the pituitary gland as the cortisol excess source and hormonal tests showed suppressed puberty markers.

This article provides an overview of diagnosing Cushing's syndrome, emphasizing the importance of assessing clinical signs and the appropriate use of first-line biochemical screening.