February 2025 in “La Pediatria Medica e Chirurgica” In this case study, a 12-year-old boy with Cushing's Disease experienced a complex diagnostic journey; ultimately, a left-side ACTH-secreting microadenoma was identified and treated with gamma knife therapy, normalizing hypercortisolism but resulting in growth hormone deficiency.
April 2019 in “Journal of the Endocrine Society” This case study reports a rare instance of ectopic ACTH secretion from a primary lung neuroendocrine tumor in a young woman, highlighting successful diagnosis and treatment following symptoms of Cushing syndrome, with normalization of ACTH, glucose, and cortisol levels post-surgery.
4 citations
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November 2021 in “Frontiers in endocrinology” This study systematically compared pediatric and adult Cushing's disease patients, revealing more severe and earlier-onset symptoms in males, and distinct gender-specific clinical manifestations.
July 2020 in “Endocrine practice” This case report details a 13-year-old boy with Cushing syndrome, where BIPSS identified the pituitary gland as the cortisol excess source and hormonal tests showed suppressed puberty markers.
42 citations
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November 2019 in “Frontiers in Endocrinology” This article provides an overview of diagnosing Cushing's syndrome, emphasizing the importance of assessing clinical signs and the appropriate use of first-line biochemical screening.
11 citations
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October 2003 in “Postgraduate Medical Journal” This study described four cases of delayed diagnosis of Cushing’s syndrome, highlighting that increased clinical awareness and screening could reduce its associated morbidity and mortality.
October 2023 in “Journal of the Endocrine Society” This study reported a rare case where a pheochromocytoma produced ACTH, leading to cyclic Cushing syndrome, and underscores the importance of considering this possibility in cases of ACTH-dependent hypercortisolism with an adrenal mass.
374 citations
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May 2016 in “The Lancet. Diabetes & endocrinology” This article reviews the clinical complications and increased mortality risks associated with Cushing's syndrome but does not present new clinical data; it emphasizes the need for prompt treatment to mitigate these risks.
June 2025 in “Journal of Endocrinological Investigation” This review identifies and discusses various endocrine-related causes of hypertension in children and adolescents, emphasizing the role of genetic predispositions and highlighting the need for systematic diagnostic guidelines and genetic sequencing referrals to improve diagnosis and treatment strategies.
3 citations
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June 2018 in “The New England Journal of Medicine” This case report describes a 45-year-old woman with persistent fatigue and confusion following hypertension treatment, who developed pulmonary embolism four weeks later.
5 citations
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May 2008 in “Annals of saudi medicine/Annals of Saudi medicine” This case report from India observed that short-term cabergoline treatment brought clinical and biochemical remission in a 12-year-old with persistent Cushing disease after surgery and radiotherapy.
October 2025 in “Journal of the Endocrine Society” In this case study, a 69-year-old woman with severe hypercortisolism developed acute adrenal insufficiency after starting ketoconazole treatment, highlighting the need for cautious dosing and close monitoring of adrenal function, particularly in patients with prior glucocorticoid exposure.
January 2025 in “JCEM Case Reports” In this case report, researchers described a patient with Cushing's Disease exhibiting no detectable mass, where Metyrapone therapy was effectively used to manage symptoms, suggesting a treatment option for similar diagnostic challenges.
April 2020 in “Journal of the Endocrine Society” In this case study, the use of somatostatin analogues was effective in localizing and confirming a neuroendocrine lung tumor as the source of ectopic ACTH syndrome, leading to marked clinical improvement in a patient unable to undergo surgery.
175 citations
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January 2020 in “European Journal of Endocrinology” These guidelines recommend testing thyroid function in patients with obesity due to common hypothyroidism, and highlight that weight loss is crucial for addressing hormonal imbalances, with only modest weight loss benefits from treating endocrine disorders.
2 citations
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January 2001 in “Humana Press eBooks” This review explores pseudo-Cushing's states that mimic Cushing's syndrome but do not involve elevated cortisol, and it presents no new research findings.
1 citations
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February 2017 in “Journal of gynecology and womens health” This review discusses the causes and management of hirsutism, recommending low-dose oral contraceptives with flutamide over cyproterone-containing preparations, but reports no new clinical findings.
January 2025 in “JCEM Case Reports” This report describes two cases of glucocorticoid resistance syndrome highlighting genetic diversity; one patient improved with low-dose dexamethasone despite negative genetic testing, while the other is monitored with a novel NR3C1 variant.
April 2020 in “Journal of the Endocrine Society” This case report describes a 45-year-old woman with recurrent cyclic Cushing’s disease whose symptoms improved with metyrapone and hydrocortisone treatment.
April 2023 in “Clinical Chemistry and Laboratory Medicine” The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.
This study found that the human hairline is closely linked to several cranial, cerebral, and vascular structures, enabling precise localization of key neuroanatomical landmarks, which could assist in planning neurosurgical procedures.
6 citations
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April 2017 in “InTech eBooks” This book discusses various unanswered questions about headaches, including genetic factors, smartphone effects, and botulinum toxin's potential benefits for chronic migraines, but reports no new clinical findings.
23 citations
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June 2010 in “Journal of Investigative Dermatology” This study found that the hair interior defect in AKR/J mice is linked to a mutation in the Soat1 gene, which disrupts SOAT1 protein expression and affects lipid metabolism critical for normal hair formation.
19 citations
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September 2006 in “Journal of Neurophysiology” In this study, researchers found that after reducing GABAergic inhibition in rats' auditory midbrain, the brain quickly compensates by increasing local neurosteroid synthesis to maintain balance in neural circuits.
3 citations
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October 2006 in “Journal of dermatology” This study reported that X-ray microscopy provides more intact images of hair's internal structure compared to transmission electron microscopy, particularly for observing fine details like cuticle coarsening and cortex cracks.
3 citations
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February 2018 in “Aesthetic plastic surgery” This study found that the locked cheek lift technique effectively corrects cheek gravitational migration and reduces the lid cheek distance with minimal complications, maintaining results for over a year.
3 citations
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August 2017 in “Oral and Maxillofacial Surgery Cases” This study observed complete resolution of neuropathic pain symptoms in a patient after a fat grafting PRP procedure, suggesting it may be a less invasive treatment alternative.
May 2024 in “IntechOpen eBooks” In this study, the authors explored the efficacy of hyperbaric oxygen therapy for typical sports injuries and cosmetic surgical wounds, finding that a hormetic dose-response relationship could explain the observed successes, contrary to prevailing expert opinion that deemed this treatment ineffective for normal wounds.
October 2022 in “Amplla Editora eBooks”