Cross-Species Comparative Spatial Transcriptomics of Hair Follicle-T Cell Interactions Identifies Conserved Drivers of Cutaneous Lupus Erythematosus Skin Disease and Associated Hair Loss

    July 2026 in “ Nature Communications ”
    Ümmügülsüm Yıldız-Altay, Rutha Adhanom, Warda Abdi, Andrew Romasco, Lauren You, Nuha Salam, Robert Li, Haya Raef, Yuying Zhang, Elise Santacruz, Katelin Murphy, Saeed Shakiba, Mridushi Daga, Qi Tang, Matthew Olivera, Thomas Cicuto, Floriane Bretheau, Ann Marshak‐Rothstein, Michael D. Rosenblum, Christina E. Baer, Motahareh Arjomandnejad, Allison M. Keeler, Helen Bui, Amanda J. Martinot, Babak Shokrani, Ramon Almela, Angel S. Byrd, Cheri Frey, Jillian M. Richmond
    Studysummary This study used spatial transcriptomics to investigate T cell-hair follicle interactions in cutaneous lupus erythematosus across mice, dogs, and humans, finding that CXCR3+ T cells and B cells are enriched in lesional skin, with implications for potential therapeutic targets.
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