Cicatricial Pattern Hair Loss Is Not a Variant of Lichen Planopilaris

    May 2020 in “ Journal of The American Academy of Dermatology ”
    Bevin Bhoyrul
    Image of study
    TLDR Cicatricial pattern hair loss is likely advanced common baldness, not a type of lichen planopilaris.
    The document, authored by Dr. Bevin Bhoyrul, challenges the classification of cicatricial pattern hair loss (CPHL) as a variant of lichen planopilaris (LPP). The author argues that CPHL is more likely to represent end-stage androgenetic alopecia (AGA) rather than a primary cicatricial alopecia. This conclusion is based on clinical observations that CPHL is asymptomatic like AGA and lacks the perifollicular erythema and scaling seen in LPP. Histologically, CPHL is characterized by features such as mild peri-infundibular or peri-isthmic lymphocytic infiltrate, concentric lamellar fibrosis, and loss of sebaceous glands, but without the interface changes in the follicular epithelium that are present in FAPD. The distinction between FAPD and CPHL is crucial for treatment decisions, as patients with LPP variants are not suitable for hair transplantation, while those with AGA may be. The author suggests that CPHL should not be considered a variant of LPP and that it represents end-stage AGA with follicular dropout and fibrosis.
    Discuss this study in the Community →

    Research cited in this study

    4 / 4 results

    Related Community Posts Join

    6 / 13 results
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community scarring alopecia awareness in this community

      in Chat  33 upvotes 2 years ago
      Lichen Planopilaris (LPP), a form of permanent hair loss, which can be mistaken for seborrheic dermatitis and is characterized by scalp itching, burning, redness, and dandruff. Treatment options discussed include steroidal creams, finasteride, minoxidil, and RU58841.

      community Exploring Bryan Johnson's Hair Routine In Detail

      in Research/Science  65 upvotes 10 months ago
      Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Finasteride not working isnt it MPB?

      in Finasteride/Dutasteride  5 upvotes 6 months ago
      A user is concerned that finasteride isn't working for their hair loss, questioning if it's due to male pattern baldness or low iron levels. They are advised to take finasteride daily and get blood work done.

    Related Research

    8 / 8 results