Synthesis, Physical Characteristics, and Biocompatibility Test of Chitosan-Alginate-Fucoidan Scaffold as an Alternative Material for Alveolar Bone Substitution

This research developed a zinc-doped nanocomposite using biodegradable materials, observing effective bone targeting and regeneration capabilities in vivo, with no observed cytotoxicity in the MG63 cell line, potentially due to blocking Farnesyl Diphosphate Synthetase to inhibit osteoclastic activity and promote osteogenesis.

This article highlights the versatility and potential of alginate and its derivatives in tissue engineering applications, discussing their properties, modification techniques, and various uses in enhancing tissue healing, bone regeneration, and cell growth.

In this study, ACF sponges with 10% fucoidan significantly promoted wound healing and hair follicle regeneration in rats, showing improved hemostatic and antibacterial performance compared to other formulations.

The document concludes that hair keratin-chitosan scaffolds were successfully made and are suitable for biomedical use.

This study found that an injectable calcium alginate-amelogenin hydrogel is biocompatible, degradable, anti-inflammatory, and promotes osteogenesis, which may enhance the bone healing process in jaw and facial bone defect areas by mediating the bone immune microenvironment.