Development and Evaluation of Biofabricated Silver Nanoparticles from Blumea Lacera for In Vitro Antibacterial, Antioxidant, and Anti-inflammatory Activity

The study focused on developing herbal silver nanoparticles (HSNPs) using Blumea lacera extracts to address microbial resistance and drug side effects. The HSNPs were synthesized by reducing silver nitrate with ethyl acetate fractions of the plant extract, confirmed by various spectroscopic methods. The nanoparticles, averaging 59.21 nm in size, showed significant antibacterial activity against Staphylococcus aureus and Escherichia coli, with zones of inhibition of 25.0±1.19 mm and 18.3±2.08 mm, respectively, and minimum inhibitory concentrations of 50 μg/ml and 60 μg/ml. While the antioxidant capacity of HSNPs was not significant compared to the extract, their anti-inflammatory activity was notable. Overall, HSNPs demonstrated superior in-vitro pharmacological potential compared to the plant extract alone.