The Intervention Effect of Externally Applying or Orally Administering Bifidobacterium Animalis Subsp. Lactis J12 on Atopic Dermatitis Induced by 2,4-Dinitrofluorobenzene

    January 2026 in “ Microorganisms ”
    Yan Zhang, Yixuan Jiang, Weilian Hong, Shaoyang Ge, Nanqing Jing, Jianjun Yang, Yuanhong Xie, H. Zhang, Junhua Jin
    TLDR Bifidobacterium animalis subsp. lactis J12 helps reduce atopic dermatitis symptoms.
    This study evaluated the effects of Bifidobacterium animalis subsp. lactis J12 on atopic dermatitis (AD) in a mouse model induced by 2,4-dinitrofluorobenzene. Involving 108 mice, the study compared oral and topical applications of J12, finding both methods significantly alleviated AD symptoms. Oral administration improved gut microbiota and systemic immune regulation, while topical application provided local anti-inflammatory benefits. Both approaches reduced inflammatory cytokines and increased regulatory T cells, suggesting J12's potential as a therapeutic option for AD through distinct mechanisms.
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