TLDR Baricitinib shows promise in improving frontal fibrosing alopecia symptoms.
In this mid-trial update on the use of baricitinib for treating frontal fibrosing alopecia (FFA), a 36-week open-label study involving 15 post-menopausal women with biopsy-proven FFA showed promising results after 12 weeks. The Lichen Planopilaris Activity Index (LPPAI) significantly decreased from 6.18 to 2.26, indicating clinical improvement in disease activity. Patient-reported outcomes for scalp hair growth improved, while eyebrow growth did not show a change. Although the pruritis score decreased, it was not statistically significant. These findings suggest baricitinib may be an effective monotherapy for FFA, but further time is needed to evaluate long-term hair growth and disease remission.
34 citations
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June 2020 in “British journal of dermatology/British journal of dermatology, Supplement” Frontal fibrosing alopecia is linked to increased immune system activity and reduced stem cells, suggesting early treatment targeting this pathway might prevent hair follicle damage.
79 citations
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September 2018 in “Dermatologic therapy” Oral tofacitinib can significantly improve recalcitrant lichen planopilaris.
339 citations
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February 2014 in “Journal of The American Academy of Dermatology” Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.
August 2022 in “IntechOpen eBooks” The best treatment for Frontal Fibrosing Alopecia and Lichen Planopilaris combines oral and topical medications to reduce symptoms and stop hair loss.
May 2023 in “Journal of Clinical Medicine” New understanding and treatments for hair loss are improving, but more research is needed.
Advancements in diagnostics, treatments, and technology have improved hair loss detection and restoration, with some types being reversible.
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March 2021 in “Clinical, Cosmetic and Investigational Dermatology” Early treatment of Lupus Erythematosus Alopecia can prevent permanent hair loss, and various medications are effective.
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May 2024 in “Dermatology and Therapy” Frontal Fibrosing Alopecia needs better diagnostics and treatments, with dutasteride showing promise.
