Tracking Down Autoantibodies in a 31-Year-Old IT Engineer Post Pfizer COVID-19 Vaccine

    April 2022 in “ Rheumatology ”
    Ripon Chandra Mazumder, Khadi S Afridi
    TLDR A man developed autoimmune symptoms after the Pfizer COVID-19 vaccine, highlighting the need for thorough vaccine safety checks.
    A 31-year-old IT engineer developed significant autoimmune symptoms immediately after receiving the Pfizer COVID-19 vaccine, despite having no prior autoimmune issues. Post-vaccination, he experienced joint pain and tested positive for multiple autoantibodies, suggesting undifferentiated connective tissue disease with potential overlap between rheumatoid arthritis and SLE. Initial treatment with prednisolone showed partial improvement, and azathioprine was added as a steroid-sparing agent. The case highlights the need for thorough safety analysis of vaccines to prevent acute and chronic autoimmune reactions.
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