Specificity of Anti-SSB as a Diagnostic Marker for the Classification of Systemic Lupus Erythematosus

April 2013 in “ Experimental and Therapeutic Medicine ”

Rao Li, Guiyan Liu, LI Chunfen, Yajuan Li, Zhiguo Wang, ZIJIAO ZHOU, Sheng-quan Tong, Xianming Wu

alopecia cheek erythema serositis secondary Sjögren's syndrome leukocytopenia elevated IgG anti-SSA60 antibodies anti-SSA52 antibodies hair loss skin redness inflammation of serous tissues secondary dry mouth and eyes low white blood cell count high immunoglobulin G

TLDR Anti-SSB antibodies are useful for diagnosing systemic lupus erythematosus and are linked to specific symptoms.

The study investigated the diagnostic value of anti-SSB antibodies in 74 SLE patients, finding them in 25.7% of SLE cases and 3.3% of controls, with a specificity of 96.7%. Anti-SSB-positive SLE patients exhibited higher rates of cheek erythema, alopecia, serositis, secondary Sjögren’s syndrome, leukocytopenia, elevated IgG, and anti-SSA60 or anti-SSA52 antibodies. The study concluded that anti-SSB antibodies are significant for diagnosing SLE and are linked to specific clinical features, recommending further molecular studies to confirm these results.

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