October 2021 in “Dermatology practical & conceptual” High-dose corticosteroids can significantly regrow hair in severe alopecia areata.
13 citations
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April 2020 in “Dermatology and therapy” This systematic review assessed cyclosporine's effectiveness with or without corticosteroids for treating alopecia areata, finding combined therapy more effective and with a lower recurrence rate than monotherapy, especially for severe cases, though results varied by alopecia type.
January 2020 in “Indian Journal of Forensic Medicine & Toxicology” In this study at Al-Diwaniyah Teaching Hospital, oral cyclosporine effectively treated 80% of patients with alopecia areata without significant adverse effects, showing promise as a safe treatment option.
17 citations
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March 2018 in “Pediatric dermatology” This study suggests that hydroxychloroquine may benefit some children with alopecia areata, as five out of nine patients showed improvement, although side effects like gastrointestinal intolerance and headache were noted.
28 citations
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January 2016 in “Dermatology” This study observed that methotrexate combined with low- to moderate-dose oral corticosteroids may effectively treat severe alopecia areata, though long-term maintenance is often necessary due to relapse after tapering.
38 citations
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January 2013 in “Dermatology” This study found that intravenous high-dose pulse corticosteroids resulted in a complete response in 38% of children with alopecia areata, but the majority of responders relapsed within a year.
14 citations
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January 2011 in “International Journal of Trichology” This study reports that combination therapy with oral steroids, anthralin, and minoxidil yielded effective cosmetic responses in 80% of patients with treatment-resistant extensive alopecia areata.
January 2009 in “Journal watch” This study enrolled nine patients to investigate the effects of oral psoralen and ultraviolet A therapy plus oral prednisolone for treating alopecia areata.
12 citations
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January 2006 in “Journal of Dermatological Treatment” This open-pilot study found that topical 1% sildenafil did not show significant hair growth in children with alopecia areata, as outcomes seemed due to spontaneous disease regression.
141 citations
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February 2005 in “Journal of the American Academy of Dermatology” In this study, oral prednisolone pulse therapy led to significant hair regrowth in some patients with extensive alopecia areata, whereas no improvement was seen in the placebo group.
1 citations
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January 2004 This study found that low-dose intermittent corticosteroid therapy may be a successful and well-tolerated treatment option for patients with alopecia areata, including those with alopecia totalis and universalis.
65 citations
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September 1999 in “The Journal of Dermatology” In this study, complete to excellent hair regrowth was observed in 63.3% of patients with extensive alopecia areata treated with biweekly dexamethasone pulses, although mild side effects were frequent.
30 citations
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August 1998 in “International Journal of Dermatology” This study found that systemic corticosteroids led to satisfactory hair regrowth in 38.9% of severe alopecia areata patients, but hair fall occurred upon therapy discontinuation or tapering.
117 citations
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February 1996 in “International Journal of Dermatology” This study found that monthly oral prednisolone pulses of 300 mg were effective and safe for treating widespread alopecia areata, with 58.3% of patients achieving cosmetically acceptable hair growth.
