Adipose Stem Cell-Derived Exosomes for Lichen Planopilaris: A Case Report

A 35-year-old female with lichen planopilaris (LPP), a scarring alopecia, showed significant improvement in hair regrowth, decreased erythema, and reduced scalp scarring after treatment with exosomes derived from adipose stem cells. This case report highlights the potential of exosomes as a novel treatment for LPP, offering a steroid-sparing option with favorable short-term side effects. Despite the promising results, the study acknowledges limitations such as the lack of long-term data and the need for larger studies to confirm efficacy and safety. Exosomes may promote hair regrowth by antagonizing dihydrotestosterone effects and facilitating the telogen-to-anagen phase transition, although their role in autoimmune activity attenuation is less understood.