Use of Adapalene in Alopecia Areata: Efficacy and Safety of Mometasone Furoate 0.1% Cream Versus Combination of Mometasone Furoate 0.1% Cream and Adapalene 0.1% Gel in Alopecia Areata

In a 2017 study involving 20 patients with alopecia areata (AA), the combination of mometasone furoate 0.1% cream and adapalene 0.1% gel (M + D) was found to be more effective than mometasone furoate 0.1% cream alone (M) in promoting hair regrowth. After 12 weeks of treatment, the M + D group exhibited a 90.5% mean hair regrowth, significantly higher than the 71% observed in the M group. Additionally, 85% of patients in the M + D group reported higher satisfaction compared to 50% in the M group. No adverse events were reported, indicating that the combination therapy is a safe and more effective option for AA treatment. The study suggests that adapalene may enhance the absorption of mometasone furoate and could have additional anti-inflammatory and immunomodulatory effects beneficial for AA, although further research with larger sample sizes is recommended.