Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche.

    Cailin Chen, Xun Li, S. M. Singh, Fernand Labrie
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    TLDR The compounds tested could potentially treat hair loss and alopecia.
    In 1998, a study was conducted on Golden Syrian hamsters to test the inhibitory effect of certain compounds on 5α-reductase, an enzyme linked to hair loss and alopecia. The compounds, including EM-401, EM-402, and EM-540, were found to be potent inhibitors of this enzyme. Specifically, EM-402 significantly reduced the size of treated flank organs and underlying sebaceous glands when applied topically. The study concluded that these compounds, particularly EM-402, could potentially be used for topical treatment of conditions related to 5α-reductase activity, such as hair loss and alopecia.
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