A woman with iatrogenic androgenetic alopecia responding to finasteride

    April 2007 in “ British Journal of Dermatology
    Jau-Shyong Hong, Hsien-Ching Chiu, Juliana C.N. Chan, Rushan Chen, Simon Lin
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    TLDR EF and PXE not closely related.
    Collagen type I, laminin and fibronectin. In addition, we analysed ABCC6 mutations in DNA from peripheral blood lymphocytes using the denaturing high-performance liquid chromatography technique. Immunohistochemical staining revealed a diffuse expressi- on of actin and desmin by many spindle cells throughout the connective tissue. Vimentin was expressed only in some of these cells (Fig. 1a). Elastic fibres stained positive with an antielastin antibody (Fig. 1b), while collagen type I and fi- bronectin were absent. Laminin stained weakly the elastic fibres and also the endothelial cells of small vessels scattered throughout the tumour. ABCC6 mutation analysis showed no abnormalities in any individual analysed. In conclusion, EF is characterized by dystrophic elastotic material with sparse cell population, most likely of mesenchy- mal origin. No mutations of the ABCC6 gene have been found in our study population; therefore, it can be concluded that EF and PXE are not closely related conditions. Further studies are necessary to elucidate the possible genetic predisposition to EF. S FERNANDEZ-FIGUEROA M DIAZ-LACAVA J RUIZ-ERTEGUN L ALCARAZ-QUILEZ F SANCHEZ-BRAVO R JIMENEZ-LUCAS V PIQUERO-PEREZ References 1 Alam M, Hynan LS. Elastofibroma: an underrecognized entity. Int J Dermatol 2003; 42:402-8. 2 Tosti A, Piraccini BM, Sertoli MR et al. Multiple familial elasto- fibromas. Eur J Dermatol 2000; 10:545-7. 3 Torrelo A, Fernandez-Flores A, Requena L. Coexistence of pseu- doxanthoma elasticum and elastofibroma cutaneous lesions suggest- ing a polygenic inheritance for both disorders. Br J Dermatol 2004; 151:1005-9. Conflicts of interest: none declared. This study looks at elastofib
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