Protective Effects of Schinus Terebinthifolius Leaf Supercritical Fluid Extract Against UVC-Induced Oxidative Stress: A Comprehensive Gene Expression Study

February 2026 in “ International Journal of Molecular Sciences ”

Tanakarn Chaithep, Anurak Muangsanguan, Juan Manuel Castagnini, Francisco J. Martí-Quijal, Pornchai Rachtanapun, Chaiwat Arjin, Korawan Sringarm, Francisco J. Barba, Warintorn Ruksiriwanich

Schinus terebinthifolius UVC-induced oxidative stress supercritical fluid extraction phenolic compounds flavonoid compounds collagenase antioxidant activity HaCaT keratinocytes ECM integrity epidermal barrier function cellular defense EGCG ascorbic acid photoprotective properties Brazilian pepper tree epigallocatechin gallate vitamin C

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Studysummary This study investigated the photoprotective properties of Brazilian pepper tree extract against UV-induced damage in skin cells, reporting that it enhanced expression of genes relevant to skin health and showed superior activity compared to standard antioxidants.

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The study demonstrates that Schinus terebinthifolius (SB) leaf extract provides significant protection against UVC-induced oxidative stress in HaCaT keratinocytes. The extract, rich in phenolic compounds like naringin, epicatechin gallate, and rosmarinic acid, showed superior antioxidant activity and enzyme inhibition compared to other extracts and standard antioxidants. SB effectively enhanced the expression of genes related to extracellular matrix integrity, skin barrier function, and antioxidant defense, suggesting its potential as a natural photoprotective agent for skincare applications. While the results are promising, further research is needed to confirm these findings in primary human cells and explore topical applications.

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research Comparative Study on Antioxidant Potential of Schinus Terebinthifolius Extracts Prepared by Conventional Extraction, Accelerated Solvent Extraction, and Pulsed Electric Field Method

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This study comparatively evaluated different extraction techniques for Schinus terebinthifolius Raddi leaf extracts and found that conventional extraction with ethanol yielded the highest antioxidant activity and beneficial effects on skin cell viability, supporting its potential use in sustainable cosmeceutical formulations targeting skin aging.

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