Protein Kinase C Delta Overexpressing Transgenic Mice Are Resistant to Chemically but Not to UV Radiation-Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2

    January 2006 in “ Cancer Research ”
    Moammir Hasan Aziz, Deric L. Wheeler, Bhushan Bhamb, Ajit Kumar Verma
    Studysummary This study found that overexpressing PKCδ in transgenic mice did not reduce squamous cell carcinoma development induced by UV radiation, despite its effectiveness against TPA-promoted cancer in these mice.
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    Research cited in this study 6

    1. Protein Kinase C Epsilon Signals Ultraviolet Light-Induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism Photochemistry and Photobiology · 2005
    2. Protein Kinase C Epsilon Is Linked to 12-O-Tetradecanoylphorbol-13-Acetate-Induced Tumor Necrosis Factor-Alpha Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase C Epsilon Transgenic Mice. PubMed · 2003
    3. Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways The Journal of Immunology · 2003
    4. Cyclooxygenase-2 Overexpression in the Skin of Transgenic Mice Results in Suppression of Tumor Development PubMed · 2002
    5. Transgenic Mice Overexpressing Protein Kinase C Epsilon in Their Epidermis Exhibit Reduced Papilloma Burden but Enhanced Carcinoma Formation After Tumor Promotion PubMed · 2000
    6. Overexpression of Protein Kinase C-α in the Epidermis of Transgenic Mice Results in Striking Alterations in Phorbol Ester-Induced Inflammation and COX-2, MIP-2, and TNF-α Expression but Not Tumor Promotion Journal of Cell Science · 1999