Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models

December 2025 in “ Pharmaceutics ”

Seokmuk Park, Seyeol Baek, Hee-Jae Shin, J. Hwang, Dae Sung Yoo, Dae Bang Seo, Seunghee Bae

araliadiol senescent human dermal fibroblasts etoposide hydrogen peroxide ultraviolet A senescence-associated secretory phenotype SASP NF-κB p65 phosphorylation MMP-1 MMP-3 extracellular procollagen type I skin aging topical therapeutic agent

Studysummary In this study, araliadiol, a plant-derived compound, exhibited senomorphic effects in three dermal fibroblast senescence models, suggesting its potential as a topical treatment to mitigate skin aging by reducing certain senescence-related markers and increasing procollagen type I content.

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