A Frameshift Insertion in SGK3 Leads to Recessive Hairlessness in Scottish Deerhounds: A Candidate Gene for Human Alopecia Conditions

    March 2019 in “ Human Genetics ”
    Marjo K. Hytönen, Hannes Lohi
    Studysummary This study identified a genetic variant in the SGK3 gene related to hairlessness in Scottish Deerhounds, suggesting a similar role for androgen-independent hair loss in humans.
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    Research cited in this study 4

    1. To Grow or Not to Grow: Hair Morphogenesis and Human Genetic Hair Disorders Seminars in Cell & Developmental Biology · 2013
    2. Expression of Foxi3 Is Regulated by Ectodysplasin in Skin Appendage Placodes Developmental dynamics · 2013
    3. Sgk3 Links Growth Factor Signaling to Maintenance of Progenitor Cells in the Hair Follicle The Journal of Cell Biology · 2005
    4. A Mutation in the Serum and Glucocorticoid-Inducible Kinase-Like Kinase (SGKL) Gene Is Associated with Defective Hair Growth in Mice DNA Research · 2004