Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells

    January 2011 in “ Journal of Clinical Investigation ”
    Luis A. Garza, Chao Yang, Tailun Zhao … George Cotsarelis
    Studysummary This study found that androgenetic alopecia may involve a defect in the conversion of hair follicle stem cells to progenitor cells, as demonstrated by a reduced presence of progenitor cells in bald scalp samples.
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    Research cited in this study 10

    1. Hedgehog Signaling Maintains Hair Follicle Stem Cell Phenotype in Young and Aged Human Skin Aging Cell · 2009
    2. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    3. Characterization and Isolation of Stem Cell-Enriched Human Hair Follicle Bulge Cells ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation · 2005
    4. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    5. Organogenesis From Dissociated Cells: Generation of Mature Cycling Hair Follicles From Skin-Derived Cells Journal of Investigative Dermatology · 2005
    6. Ber-EP4 Antigen Is a Marker for a Cell Population Related to the Secondary Hair Germ Experimental Dermatology · 2004
    7. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    8. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    9. Treatment of Hair Loss The New England Journal of Medicine · 1999
    10. The Biology of Hair Follicles The New England Journal of Medicine · 1999

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    5. Male Androgenetic Alopecia Is Due to Hair Follicle Stem Cell Inactivation Expert Review of Dermatology · 2011
    6. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011
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