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research Single-Cell RNA Sequencing Reveals Cellular and Transcriptional Changes Associated With M1 Macrophage Polarization in Hidradenitis Suppurativa

22 citations , August 2021 in “Frontiers in medicine”

This study found that monocytes/macrophages with a pro-inflammatory M1-like phenotype may play a crucial role in the pathogenesis of hidradenitis suppurativa, suggesting potential therapeutic targets.

research Understanding the Nano‐topography Changes and Cellular Influences Resulting from the Surface Adsorption of Human Hair Keratins

41 citations , May 2012 in “Advanced Healthcare Materials”

This study found that human hair keratin coatings enhanced adhesion and proliferation of L929 mouse fibroblasts compared to uncoated and collagen type 1 surfaces, suggesting keratin's potential as a surface coating for cell cultures.

research Finasteride improves motor, EEG, and cellular changes in rat brain in thioacetamide-induced hepatic encephalopathy

17 citations , August 2014 in “American Journal of Physiology-gastrointestinal and Liver Physiology”

This study found that finasteride significantly improved motor, EEG, and cellular changes in a rat model of thioacetamide-induced hepatic encephalopathy and prevented the development of hepatic coma.

research The Pathological Changes and Polymorphonuclear and Mast Cell Responses in the Skin of Specific Pathogen‐free Lambs Following Primary and Secondary Challenge with Orf Virus

18 citations , September 1990 in “Veterinary Dermatology”

This study in SPF lambs found that primary and secondary orf virus infections trigger similar skin responses, but the primary infection caused a more severe and prolonged reaction.

research Do Changes in Chromosomes Cause Aging?

50 citations , July 1996 in “Cell”

This review discusses genetic and epigenetic mechanisms that may contribute to aging and presents models suggesting that chromosomal changes could play a key role in the aging process; it reports no new experimental findings.

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Community Join

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community My Theory Of Androgenic Alopecia

16 upvotes 10 months ago

Hair loss is linked to cellular physiology and the IGF-1 to TGF-B1 ratio, not just androgen sensitivity. The theory lacks evidence, while finasteride and minoxidil are effective treatments.

community Taking creatine while on finasteride

51 upvotes 3 years ago

Creatine does not significantly affect hair loss when taking finasteride. Some users report no change, while others believe it may accelerate hair loss if predisposed to male pattern baldness.

community Study: There is 70x Higher Unconjugated DHT in Feces Compared To Blood Levels in Young Adults - Gut Microbiota Manages DHT Recycling and Metabolism

in Research/Science 194 upvotes 1 year ago

Gut microbiota significantly influences androgen metabolism, impacting hair loss treatments like finasteride. Probiotics, dietary changes, and fecal microbiota transplants may help manage DHT levels and improve hair health.

community How ET-02 Works. Also no proof that it's better than Minoxidil. At least for now.

44 upvotes 1 year ago

ET-02, a PAI-1 inhibitor, is not proven to be more effective than Minoxidil for hair loss. Other treatments like finasteride, dutasteride, PP405, and AMP-303 are also discussed, focusing on cellular senescence and oxidative stress.

community Pyrilutamide ,the molecule’s true nature

in Research 302 upvotes 2 years ago

Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

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Learn

4 / 800 results

learn Stem Cell Factor

learn Thymosin Beta 4

learn vitamin b2

How does Vitamin B2 support scalp circulation and cellular energy production? Vitamin B2 enhances scalp circulation and energy production by supporting cellular metabolism.

learn Folic acid

How does folic acid support hair follicle health and growth at a cellular level? Folate is required for the DNA synthesis that fast-dividing hair matrix cells depend on, and severe deficiency causes anemia—but no published trial has given folic acid to people with hair loss and measured the result, so a growth effect is a mechanism, not a finding.

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