Major Improvement in Wound Healing Through Pharmacologic Mobilization of Stem Cells in Severely Diabetic Rats
January 2020
in “
Diabetes
”
wound healing diabetic rats AF combination therapy AMD3100 FK506 type 1 diabetes type 2 diabetes scarring hair follicles bone marrow-derived CD133+ cells bone marrow-derived CD34+ cells endothelial progenitor cells anti-inflammatory macrophage phenotypes capillary neogenesis hair follicle neogenesis microcirculation diabetic angiopathy diabetic foot ulcers stem cells diabetes foot ulcers
Studysummary In this study using diabetic rat models, the combination of AMD3100 and low-dose FK506 reduced wound healing time and improved microcirculation in diabetic foot ulcers, indicating a promising new systemic therapy.
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