Protective Effect of DA-9401 in Finasteride-Induced Apoptosis in Rat Testis: Inositol Requiring Kinase 1 and c-Jun N-Terminal Kinase Pathway

October 2017 in “ Drug Design Development and Therapy ”

Kiran Kumar Soni, Yu Seob Shin, Bo Youl Choi, Keshab Kumar Karna, Hyung Sik Kim, Sung Koo Lee, Chul Sung Kim, Jong Chun Park

finasteride DA-9401 apoptosis inositol requiring kinase 1 c-Jun N-terminal kinase 5α-reductase inhibitors hypothalamic-pituitary-testicular axis Propecia

Studysummary The study found that finasteride increased endoplasmic reticulum stress and reduced fertility in rats, effects that were alleviated by the administration of DA-9401.

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The study investigated the protective effect of DA-9401 on finasteride-induced apoptosis in rat testis. Finasteride caused infertility and apoptosis in testicular tissue, but DA-9401 was found to attenuate these effects. The study suggests that DA-9401 may have a protective effect against finasteride-induced apoptosis in rat testis through the inositol requiring kinase 1 and c-Jun N-terminal kinase pathway. Further studies are needed to understand the interaction between 5α-reductase inhibitors and DA-9401 in the hypothalamic-pituitary-testicular axis in humans.

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