Spontaneous Tumor Regression in Keratoacanthomas Is Driven by Wnt/Retinoic Acid Signaling Cross-Talk

March 2014 in “ Nature Communications ”

Giovanni Zito, Ichiko Saotome, Zongzhi Liu, Enrico Ferro, Thomas Sun, Don X. Nguyen, Kaya Bilgüvar, Christine J. Ko, Valentina Greco

keratoacanthomas retinoic acid Wnt signaling nuclear β-catenin Wnt inhibitors differentiation programs squamous cell carcinomas RA treatment KAs RA SCCs

Studysummary This study suggests that activating retinoic acid signalling can inhibit Wnt signalling and induce regression in certain skin tumors, providing potential therapeutic strategies for tumor regression.

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research Towards Dissecting the Pathogenesis of Retinoid-Induced Hair Loss: All-Trans Retinoic Acid Induces Premature Hair Follicle Regression by Upregulation of Transforming Growth Factor-β2 in the Dermal Papilla

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research Canonical WNT Signaling Promotes Mammary Placode Development and Is Essential for Initiation of Mammary Gland Morphogenesis

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