October 2024 in “Journal of the Endocrine Society” In this case study, a postmenopausal woman with symptoms of virilization was diagnosed with a rare ovarian Leydig cell tumor, and surgical removal led to a resolution of her hyperandrogenism and related symptoms, highlighting the importance of thorough differential diagnosis in postmenopausal hyperandrogenism.
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February 2016 in “European Journal of Obstetrics & Gynecology and Reproductive Biology” This case study reports that medical imaging of the ovaries may not always conclusively identify the cause of postmenopausal hyperandrogenism, as demonstrated by a patient with a rare condition.
October 2025 in “Journal of the Endocrine Society” This case study reported that sudden hyperandrogenism in postmenopausal women may indicate hormonally active ovarian tumors such as Leydig cell tumors, which can be effectively treated with surgery.
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January 2021 in “touchREVIEWS in Endocrinology” This case report describes how a 68-year-old woman's hyperandrogenic symptoms improved and testosterone levels normalized after the surgical removal of an occult Leydig cell tumour.
October 2024 in “Journal of the Endocrine Society” In this case report, researchers described a postmenopausal woman with virilization symptoms who was diagnosed with a Leydig cell tumor in her ovary, and symptoms improved following tumor removal. The authors highlighted the diagnostic challenge of differentiating such cases from age-related hormonal changes.
