SUN-115 Leydig Cell Tumor: A Rare Cause of Hyperandrogenism
October 2025
in “
Journal of the Endocrine Society
”
Studysummary This case study reported that sudden hyperandrogenism in postmenopausal women may indicate hormonally active ovarian tumors such as Leydig cell tumors, which can be effectively treated with surgery.
Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer
Leydig cell tumors of the ovary, though rare and benign, can cause significant hyperandrogenism in postmenopausal women, as illustrated by a 72-year-old patient who experienced virilization symptoms such as voice deepening and male pattern hair loss. Initially misattributed to Anastrozole, her elevated testosterone levels persisted until an MRI revealed a 2 cm Leydig cell tumor on her left ovary. Surgical removal of the tumor via bilateral salpingo-oophorectomy normalized her testosterone levels and resolved her symptoms, including hair regrowth. This case underscores the importance of considering ovarian tumors in postmenopausal women with sudden hyperandrogenism, as these tumors are curable with surgery, though long-term follow-up is necessary to monitor for recurrence.
