An Occult Leydig Cell Tumor in a Postmenopausal Woman Presenting with Alopecia and Hirsutism: A Case Report

January 2021 in “ touchREVIEWS in Endocrinology ”

Shuann Shwana, Natasha Shrikrishnapalasuriyar, Win Yin, Monica Vij, Atul Kalhan

alopecia hirsutism testosterone androgens dehydroepiandrosterone sulphate 17-hydroxyprogesterone Leydig cell tumour hyperandrogenic symptoms hair loss facial hair growth DHEA-S 17-OHP

Studysummary This case report describes how a 68-year-old woman's hyperandrogenic symptoms improved and testosterone levels normalized after the surgical removal of an occult Leydig cell tumour.

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research Hyperandrogenism in a Postmenopausal Woman Secondary to Testosterone-Secreting Ovarian Stromal Tumor with Acoustic Schwannoma

4 citations , December 2018 in “Case reports in endocrinology”

This case study reported a postmenopausal woman with a testosterone-secreting ovarian tumor that was not detected through standard clinical or radiological examination but was found via biopsy.

research An Ovarian Leydig Cell Tumor Undetected by Ultrasound in a Postmenopausal Woman with Hirsutism and Hyperandrogenism

12 citations , March 2018 in “Medicine”

This case report describes a 60-year-old woman with an ovarian Leydig cell tumor leading to elevated testosterone levels and hirsutism, highlighting the need to consider androgen-secreting tumors in similar postmenopausal cases.

Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

research Discriminating Between Virilizing Ovary Tumors and Ovary Hyperthecosis in Postmenopausal Women: Clinical Data, Hormonal Profiles, and Imaging Studies

27 citations , April 2017 in “European journal of endocrinology”

This retrospective study found that serum hormone levels and MRI detection of ovarian nodules contributed to distinguishing virilizing ovarian tumors from ovarian stromal hyperthecosis in postmenopausal women, though histopathology remains crucial for diagnosis.

research Ovarian Leydig Cell Tumor in a Post-Menopausal Patient with Severe Hyperandrogenism

22 citations , February 2014 in “Arquivos Brasileiros De Endocrinologia E Metabologia”

An 81-year-old woman's severe male hormone symptoms were caused by an ovarian tumor, which was treated with surgery.

research How Should Postmenopausal Androgen Excess Be Evaluated?

63 citations , March 2011 in “Clinical Endocrinology”

This review examines the evaluation and management of hirsutism and hyperandrogenism in postmenopausal women and reports no new clinical findings.

Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

research Assessment of Cardiovascular Risk and Prevention of Cardiovascular Disease in Women with Polycystic Ovary Syndrome: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

815 citations , April 2010 in “The Journal of Clinical Endocrinology & Metabolism”

This review examines the relationship between polycystic ovary syndrome and cardiovascular disease risk, but reports no new clinical findings; the panel calls for guidelines to prevent CVD in this population.

research Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline

502 citations , February 2008 in “The Journal of Clinical Endocrinology & Metabolism”

This review discusses hirsutism management guidelines, recommending androgen testing only for women with abnormal hirsutism scores and advocating for combined therapy approaches depending on severity and underlying conditions, but it reports no new clinical results.