Ovarian Leydig Cell Tumor and Postmenopausal Hirsutism with Signs of Virilization

March 2021 in “ Case Reports ”

Catia Ferrinho, Eugénia Silva, Manuela Oliveira, João Sequeira Duarte

hirsutism virilization androgen levels Leydig cell tumor hyperandrogenism endometrial carcinoma

Studysummary In this case study, a 71-year-old woman with postmenopausal hirsutism was diagnosed with a Leydig cell tumor and endometrial carcinoma, with hirsutism improving one month after surgery.

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Research cited in this study

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Menopausal Androgen Excess-Associated Cardio-Metabolic Risk: Clues for Ovarian Leydig Cell Tumor (Case Report and Mini-Review of Literature)

research Menopausal Androgen Excess-Associated Cardio-Metabolic Risk: Clues for Ovarian Leydig Cell Tumor (Case Report and Mini-Review of Literature)

5 citations , January 2017 in “Acta Endocrinologica”

This case report discusses a postmenopausal woman whose hyperandrogenism and metabolic symptoms improved significantly after the surgical removal of an ovarian Leydig cell tumor, confirmed post-operatively.

research Management of Endocrine Disease: Hyperandrogenism After Menopause

84 citations , September 2014 in “European journal of endocrinology”

This review examines the causes and characteristics of androgen excess in postmenopausal women, but reports no new clinical results; the authors emphasize challenges in diagnosis and potential long-term health impacts.

research Ovarian Leydig Cell Tumor in a Post-Menopausal Patient with Severe Hyperandrogenism

22 citations , February 2014 in “Arquivos Brasileiros De Endocrinologia E Metabologia”

An 81-year-old woman's severe male hormone symptoms were caused by an ovarian tumor, which was treated with surgery.

Epidemiology, Diagnosis, and Management of Hirsutism: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

research Epidemiology, Diagnosis, and Management of Hirsutism: A Consensus Statement by the Androgen Excess and Polycystic Ovary Syndrome Society

378 citations , November 2011 in “Human reproduction update”

This review discusses the epidemiology, causes, diagnosis, and management of hirsutism in women, noting that effective treatment requires addressing the root cause as well as the hair growth.

research How Should Postmenopausal Androgen Excess Be Evaluated?

63 citations , March 2011 in “Clinical Endocrinology”

This review examines the evaluation and management of hirsutism and hyperandrogenism in postmenopausal women and reports no new clinical findings.

research Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline

502 citations , February 2008 in “The Journal of Clinical Endocrinology & Metabolism”

This review discusses hirsutism management guidelines, recommending androgen testing only for women with abnormal hirsutism scores and advocating for combined therapy approaches depending on severity and underlying conditions, but it reports no new clinical results.