Mutations in the Serum/Glucocorticoid Regulated Kinase 3 (SGK3) Are Responsible for the Mouse Fuzzy (FZ) Hair Phenotype

October 2007 in “ Journal of Investigative Dermatology ”

Dean R. Campagna, Ángel O. Custodio, Brendan Antiochos, Marius V. Cirlan, Mark D. Fleming

Serum/Glucocorticoid Regulated Kinase 3 Sgk3 hair follicle development hair follicle cell proliferation hair follicle differentiation hair follicle migration fuzzy hair phenotype gene mutation fuzzy hair

Studysummary Mutations in the Sgk3 gene cause fuzzy hair in mice.

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research The Critical Roles of Serum/Glucocorticoid-Regulated Kinase 3 (SGK3) in Hair Follicle Morphogenesis and Homeostasis

9 citations , April 2006 in “American Journal of Pathology”

This study found that mutations in the Sgk3 gene cause defective hair follicle development and altered hair cycling in mice, with variable phenotypic outcomes depending on different dysfunction patterns of the SGK3 protein.

research Sgk3 Links Growth Factor Signaling to Maintenance of Progenitor Cells in the Hair Follicle

53 citations , August 2005 in “The Journal of Cell Biology”

This study found that the absence of Sgk3 in mice leads to impaired hair follicle maturation, characterized by reduced cell proliferation, increased apoptosis, and premature regression.

research Premature Termination of Hair Follicle Morphogenesis and Accelerated Hair Follicle Cycling in Iasi Congenital Atrichia (fzica) Mice Points to Fuzzy as a Key Element of Hair Cycle Control

20 citations , July 2005 in “Experimental dermatology”

This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.

research A Mutation in the Serum and Glucocorticoid-Inducible Kinase-Like Kinase (SGKL) Gene Is Associated with Defective Hair Growth in Mice

6 citations , January 2004 in “DNA Research”

This study identified a nonsense mutation in the Sgkl gene as the cause of defective hair growth in a mutant mouse strain, implicating the SGKL signaling pathway in hair development.