Abnormal Neuronal Differentiation and Mitochondrial Dysfunction in Hair Follicle-Derived Induced Pluripotent Stem Cells of Schizophrenia Patients

June 2013 in “ Molecular psychiatry ”

O Robicsek, Rachel Karry, Isabelle Petit, N Salman-Kesner, Franz‐Josef Müller, Ehud Klein, Daniel Aberdam, Dorit Ben‐Shachar

hair follicle keratinocytes induced pluripotent stem cells iPSCs neuronal differentiation dopaminergic neurons glutamatergic neurons mitochondrial dysfunction mitochondrial membrane potential mitochondrial network structure stem cells neurons mitochondria

Studysummary This study found that schizophrenia-derived neurons exhibited impaired differentiation and mitochondrial dysfunction, suggesting a potential link between these factors and neurodevelopmental processes in schizophrenia.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer ·

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