Therapeutic Potential of Nerve Growth Factor-Modified Hair Follicle Stem Cells Transplantation in a Rat Model of Alzheimer's Disease

    February 2026 in “ Journal of Integrative Neuroscience ”
    Dan Yang, Lina Liu, Jia Fu
    Studysummary In this study, transplantation of hair follicle stem cells and nerve growth factor-modified stem cells significantly reduced amyloid deposition and tau hyperphosphorylation in an Alzheimer's disease rat model, suggesting potential as a treatment option.
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    Research cited in this study 5

    1. Hepatocyte Growth Factor-Modified Hair Follicle Stem Cells Ameliorate Cerebral Ischemia/Reperfusion Injury in Rats Stem Cell Research & Therapy · 2023
    2. Comparative Characterization and Osteogenic/Adipogenic Differentiation of Mesenchymal Stem Cells Derived from Male Rat Hair Follicles and Bone Marrow Cell regeneration · 2020
    3. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2019
    4. Multipotent Neural Crest Stem Cell-Like Cells from Rat Vibrissa Dermal Papilla Induce Neuronal Differentiation of PC12 Cells BioMed research international · 2014
    5. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005