5α-Reductase Inhibitors: Chemical and Clinical Models

    May 1998 in “ Steroids ”
    Antonio Guarna, Ernesto G. Occhiato, Giovanna Danza … Mario Serio
    Studysummary This study constructed a model to predict finasteride's inhibitory activity on 5α-reductase type 2 and calculated that a 1 μM plasma concentration, after 50 mg administration, matches prostate inhibition levels.
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    Research cited in this study 7

    1. Outcome of Long-Term Treatment with the 5α-Reductase Inhibitor Finasteride in Idiopathic Hirsutism: Clinical and Hormonal Effects During a 1-Year Course of Therapy and 1-Year Follow-Up Fertility and Sterility · 1996
    2. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
    3. Synthesis of 5,6,6-[2H3]Finasteride and Quantitative Determination of Finasteride in Human Plasma at Picogram Level by an Isotope-Dilution Mass Spectrometric Method Journal of Chromatography B: Biomedical Sciences and Applications · 1995
    4. The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase Steroids · 1995
    5. Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995
    6. The Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Scalp Skin Testosterone and Dihydrotestosterone Concentrations in Patients With Male Pattern Baldness The Journal of Clinical Endocrinology and Metabolism · 1994
    7. High-Performance Liquid Chromatographic Method for the Determination of Finasteride in Human Plasma at Therapeutic Doses Journal of Chromatography B: Biomedical Sciences and Applications · 1991

    Related research 1

    1. Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α-Reductase Inhibitor Bioorganic & Medicinal Chemistry Letters · 2010