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research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

13 citations , January 2015 in “Steroids”

This study generated a pharmacophoric model for both isoforms of steroidal 5α-reductase using 6-azasteroids, providing a structural framework for designing new inhibitors.

research Synthesis and 5α-Reductase Inhibitory Activity of C21 Steroids Having 1,4-diene or 4,6-diene 20-ones and 4-Azasteroid 20-Oximes

186 citations , December 2011 in “Molecules”

This study reported that while no synthesized compounds surpassed finasteride in 5α-reductase inhibitory activity, certain 4-azasteroid-2-oximes exhibited notable inhibition.

research 5α-Reductase Inhibitors, Chemical and Clinical Models

17 citations , May 1998 in “Steroids”

This study constructed a model to predict finasteride's inhibitory activity on 5α-reductase type 2 and calculated that a 1 μM plasma concentration, after 50 mg administration, matches prostate inhibition levels.

research Alopecia - the search for novel agents continues

11 citations , August 1997 in “Expert Opinion on Therapeutic Patents”

This review discusses nearly 70 patent applications for the treatment of androgenetic alopecia and other hair conditions, highlighting the mechanisms of action explored but reports no clinical results.

research Design and synthesis of novel Azasteroids and Pseudoazulenyl nitrones

December 2016

This review explores the synthesis and potential of azasteroids as novel drugs, discussing challenges in their production and reporting no new clinical results.

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community Finasteride, dutasteride, and oral min- My experience

in Finasteride/Dutasteride 126 upvotes 5 years ago

User took Fin for 3 years, Dut for 7 months, and oral Min for 2 months without side effects. Fin stopped hair loss for 2 years, Dut maintained hair, and oral Min regrew thinning hair.

community 6 Months of treatment fin + min and dut + min

13 upvotes 2 days ago

The user started a hair loss treatment with finasteride and minoxidil, then switched to dutasteride and minoxidil, experiencing increased body hair and reduced alcohol tolerance. They plan to get a hair transplant in 12 months and have received compliments on their eyelashes.

community 6 week shed is over, now give me some regrowth fgs

10 upvotes 3 days ago

The user experienced significant hair shedding after starting 2.5mg oral minoxidil daily, which lasted from week 3 to week 5, but now hopes for regrowth. Other users encouraged patience, suggesting noticeable improvement by the one-year mark.

community 6 MONT 0,5 DUT and oral minoxidil 5 and 6%

40 upvotes 1 week ago

The user experienced hair regrowth after six months using 0.5 mg dutasteride and 5 mg oral minoxidil with 6% topical minoxidil. Some users suggested adding microneedling for further improvement.

community 6 months progress Finasteride & minoxidil

15 upvotes 1 week ago

The user experienced hair regrowth using minoxidil and finasteride but lost progress after inconsistent use. They are now committed to using these treatments consistently and have adopted a healthier lifestyle.

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Learn

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learn omega-6

learn Omega 3

Is the omega-3 to omega-6 ratio in your diet feeding your hair problem without you knowing? Nutrition sources describe a lopsided omega-6 to omega-3 intake as pro-inflammatory, but no published human study shows that the dietary ratio changes 5-alpha reductase, scalp DHT or hair loss; the one relevant trial tested a commercial omega-3/6 plus antioxidant supplement in 120 women, not a change in dietary fat ratio.

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