Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis
January 2016
in “
Journal of Investigative Dermatology
”
IL-6 interleukin-6 IL-6 knockout IL-6 KO wild-type mice WT mice wound-induced hair neogenesis WIHN oncostatin M OSM interleukin 11 IL-11 phosphorylated Stat3 P-Stat3 Stat3 signaling cucurbitacin I JAK2/STAT3 hair follicle regeneration cytokine signaling ligand compensation hair neogenesis Stat3 hair regeneration
Studysummary This study found that IL-6 knockout mice exhibited increased wound-induced hair neogenesis compared to wild-type mice, likely due to enhanced STAT3 activation facilitated by compensatory cytokine activity.
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