Tracing the Change and Contribution of Subcutaneous Adipose to Skin Expansion Using a Luciferase-Transgenic Fat Transplantation Model

    May 2023 in “ Plastic & Reconstructive Surgery ”
    Shuang‐Bai Zhou, Pei-Qi Zhang, Xiaojie Zhang … Qingfeng Li
    Studysummary This study found that transplanting adipose tissue into the rat dorsum supported long-term skin expansion by enhancing thickness, vascularization, and cell proliferation, with adipose-derived cells actively contributing to skin regeneration and growth factor expression.
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    Research cited in this study 7

    1. A Randomized, Controlled Clinical Trial of Autologous Stromal Vascular Fraction Cells Transplantation to Promote Mechanical Stretch-Induced Skin Regeneration Stem Cell Research & Therapy · 2021
    2. Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice Journal of Clinical Investigation · 2019
    3. Macrophages Are Necessary for Skin Regeneration During Tissue Expansion Journal of Translational Medicine · 2019
    4. Leptin Controls Hair Follicle Cycling Experimental Dermatology · 2014
    5. Mechanical Stretch Upregulates SDF-1α in Skin Tissue and Induces Migration of Circulating Bone Marrow-Derived Stem Cells into the Expanded Skin Stem Cells · 2013
    6. Scalp Repair Using Tissue Expanders Facial Plastic Surgery Clinics of North America · 2013
    7. Tissue Expansion and Serial Excision in Scar Revision Facial Plastic Surgery · 2001