Structure and Expression of the Ovine Hoxc-13 Gene

December 2003 in “ Gene ”

Guy R. Sander, Barry C. Powell

Hoxc-13 keratin Abd-B type I Homeobox genes LEF-1 Whn/Foxn1 hair follicles skin function Homeobox genes LEF-1 transcription factor Foxn1 transcription factor

Studysummary This study characterized the Hoxc-13 gene from sheep wool follicles, noting its potential autoregulatory role and potential influence on skin function beyond hair keratin regulation.

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research HOXC13 Is Involved in the Regulation of Human Hair Keratin Gene Expression

132 citations , February 2002 in “Journal of Biological Chemistry”

This study demonstrated that HOXC13 directly influences hair keratin gene expression by binding to specific DNA motifs, suggesting its role in early hair follicle differentiation.

research Overexpression of Hoxc13 in Differentiating Keratinocytes Results in Downregulation of a Novel Hair Keratin Gene Cluster and Alopecia

114 citations , May 2001 in “Development”

This study found that overexpressing the Hoxc13 gene in mice causes hair loss and a skin condition similar to ichthyosis, identifying several gene targets that may regulate hair growth.

research Genetically Separable Determinants of Hair Keratin Gene Expression

27 citations , January 2000 in “Developmental Dynamics”

This study reports that a new nude allele, nu(StL), encodes a truncated Whn transcription factor affecting T-cell development and keratin gene expression, with notable differences from the original Whn(nu) mutation.

research Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation

990 citations , October 1999 in “Development”

This study found that LEF1/TCF3 is necessary but not sufficient for TOPGAL activation in hair follicle development, indicating complex regulation in the skin.

research Hoxc13 Mutant Mice Lack External Hair

245 citations , January 1998 in “Genes & Development”

This study found that Hoxc13 mutations in mice cause defects in hair, nail, and tongue structures, with the most noticeable issue being brittle hair leading to alopecia.

research The Role of Keratin Proteins and Their Genes in the Growth, Structure, and Properties of Hair

228 citations , January 1997 in “Birkhäuser Basel eBooks”

This article integrates existing literature on hair follicle structure and formation at the cellular and molecular level, reporting no new findings.

research Sequence and Expression of Murine Type I Hair Keratins mHa2 and mHa3

47 citations , June 1994 in “Experimental Cell Research”

mHa2 and mHa3 keratins have different structures and roles in mouse hair and tongue tissues.

research Structural Features and Sites of Expression of a New Murine 65 kD and 48 kD Hair-Related Keratin Pair, Associated with a Special Type of Parakeratotic Epithelial Differentiation

28 citations , August 1992 in “Differentiation”

This study identified a new 65 kD and 48 kD keratin pair expressed in specific mouse epithelial sites, suggesting a unique evolutionary branch of hair-related keratins.

research Hard Keratin Intermediate Filaments and Associated Proteins

22 citations , January 1990

research Expression of Hair-Related Keratins in a Soft Epithelium: Subpopulations of Human and Mouse Dorsal Tongue Keratinocytes Express Keratin Markers for Hair, Skin, and Esophageal Types of Differentiation

128 citations , March 1989 in “Experimental Cell Research”

Hoxc13 is important for hair and tongue development by controlling hair keratin genes.