Avicequinone C Isolated from Avicennia Marina Exhibits 5α-Reductase Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System

    May 2014 in “ Molecules ”
    Ruchy Jain, Orawan Monthakantirat, Parkpoom Tengamnuay, Wanchai De-Eknamkul
    Studysummary This study found that the methanolic heartwood extract of Avicennia marina significantly inhibits 5α-reductase type 1, reducing 5α-DHT production by 52% in a cell-based assay with human hair dermal papilla cells.
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    Research cited in this study 17

    1. The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases Advances in Urology · 2011
    2. 5α-Reductase Inhibition and Hair Growth Promotion of Some Thai Plants Traditionally Used for Hair Treatment Journal of Ethnopharmacology · 2011
    3. Inhibitory Activities of Puerariae Flos Against Testosterone 5α-Reductase and Its Hair Growth Promotion Activities Journal of Natural Medicines · 2011
    4. Potency of a Novel Saw Palmetto Ethanol Extract, SPET-085, for Inhibition of 5α-Reductase II Advances in Therapy · 2010
    5. 5α-Reductase Inhibitory Components as Antiandrogens From Herbal Medicine Journal of acupuncture and meridian studies · 2010
    6. Effect of Cuscuta Reflexa Roxb on Androgen-Induced Alopecia Journal of Cosmetic Dermatology · 2008
    7. Testosterone 5-Alpha-Reductase Inhibitory Active Constituents of Piper Nigrum Leaf Biological & pharmaceutical bulletin · 2007
    8. Psychological Effect, Pathophysiology, and Management of Androgenetic Alopecia in Men Mayo Clinic Proceedings · 2005
    9. Role of Androgen in Mesenchymal Epithelial Interactions in Human Hair Follicle Journal of Investigative Dermatology Symposium Proceedings · 2005
    10. The Hair Growth Promoting Effect of Asiasari Radix Extract and Its Molecular Regulation Journal of Dermatological Science · 2005
    11. Torilin from Torilis Japonica as a New Inhibitor of Testosterone 5α-Reductase Planta Medica · 2003
    12. Androgenetic Alopecia: Pathogenesis and Potential for Therapy Expert Reviews in Molecular Medicine · 2002
    13. The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation Journal of Dermatological Science · 2002
    14. Anti-Androgenic and Hair Growth Promoting Activities of Lygodii Spora (Spore of Lygodium Japonicum): Active Constituents Inhibiting Testosterone 5α-Reductase Biological & Pharmaceutical Bulletin · 2002
    15. Immunohistochemical Localization of Types 1 and 2 5α-Reductase in Human Scalp British Journal of Dermatology · 1999
    16. The 5 Alpha-Reductase System and Its Inhibitors Dermatology · 1996
    17. The Control of Hair Growth: An Overview Journal of Investigative Dermatology · 1993

    Related research 6

    1. Mechanistic Synergy of Hair Growth Promotion by the Avicennia Marina Extract and Its Active Constituent Avicequinone C in Dermal Papilla Cells Isolated From Androgenic Alopecia Patients PLOS ONE · 2023
    2. Induction of Cell Proliferation and Cell Death in Human Follicle Dermal Papilla Cells by Zinc Chloride Indian Journal of Pharmaceutical Sciences · 2019
    3. Identification of a New Plant Extract for Androgenic Alopecia Treatment Using a Non-Radioactive Human Hair Dermal Papilla Cell-Based Assay BMC Complementary and Alternative Medicine · 2015
    4. Avicequinone C Isolated from Avicennia Marina Exhibits 5α-Reductase Type 1 Inhibitory Activity Using an Androgenic Alopecia Relevant Cell-Based Assay System Molecules · 2014
    5. 5α-Reductase Activity in the Human Hair Follicle Concentrates in the Dermal Papilla Archives of Dermatological Research · 1998
    6. Effects of Testosterone, Dihydrotestosterone, and Estradiol on Growth of Human Hair Outer Root Sheath Keratinocytes In Vitro Archives of Dermatological Research · 1991