Cyproterone Acetate Quantification in Human Plasma by High-Performance Liquid Chromatography Coupled to Atmospheric Pressure Photoionization Tandem Mass Spectrometry

    December 2011 in “ Arzneimittelforschung
    Ney Carter do Carmo Borges, Ana Cristina Mazuqueli, Ronílson Agnaldo Moreno, Rafael Barrientos Astigarraga, Carlos Sverdloff, Paulo Alexandre Rebelo Galvinas, Mauício Sampaio, Washington Moreira da Silva
    From the encyclopedia
    Cyproterone →

    a synthetic anti-androgen and weak progestogen that inhibits DHT binding to androgen receptor

    Finasteride →

    Frontline, gold standard treatment for combatting androgenic alopecia

    Studysummary This study developed a sensitive HPLC-MS/MS method for determining cyproterone acetate levels in human plasma and found no significant difference in its concentration between two oral formulations in bioequivalence testing.
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