Safety and Tolerability of Combination Oral Spironolactone and Low-Dose Oral Minoxidil for Hair Loss in Adult Females: A Retrospective Cohort Study
February 2026
in “
Journal of the American Academy of Dermatology
”
Studysummary In this retrospective study, researchers found that while combination therapy of spironolactone and oral minoxidil for female alopecia commonly led to mild outpatient-manageable side effects, starting both medications simultaneously reduced hypertrichosis risk, but taking multiple blood pressure medications increased hypotensive symptoms.
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