7DHC and BM15766 Treated Mice (C57BL/6; n = 5) Failed to Regrow Hair

September 2025 in “ OPAL (Open@LaTrobe) (La Trobe University) ”

Leemon Nikhila (22250736), Suresh Surya (22250739), Shahul Hameed Najeeb (22250742), Thankachan Mangalathettu Binumon (22250745), Aayush Gupta (9580239), Sandeep Gopalakrishnan (334402), Mahsa Dabagh (3972137), Parameswara Panicker Sreejith (22250748)

7DHC BM15766 LGR5 WNT 5A SOX9 SHH BrdU apoptotic cells DNA-damaged cells

TLDR The treatments stopped hair regrowth in mice.

A study involving 5 C57BL/6 mice examined the effects of topical treatments 7DHC and BM15766 on hair growth. The treatments led to reduced hair growth compared to the Ethanol/DMSO vehicle-treated group, which successfully regrew hair. Gene expression analysis showed down-regulation of LGR5, WNT 5A, SOX9, and SHH in treated mice. Additionally, BrdU labeling did not indicate stem cell retention in treated mice, unlike controls. TMR red imaging revealed more apoptotic or DNA-damaged cells in treated samples compared to controls.

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