RGDSP-Functionalized Peptide Hydrogel Stimulates Growth Factor Secretion Via Integrin αv/PI3K/AKT Axis for Improved Wound Healing by Human Amniotic Mesenchymal Stem Cells

October 2024 in “ Frontiers in Bioengineering and Biotechnology ”

Wei Wei, Lei Huang, Luoying Chen, Huanhuan He, Yanfei Liu, Yuan Ping Feng, Feng-Qin Lin, Hui Chen, Qing‐Yu He, Junhong Zhao, Haihong Li

RGDSP-functionalized peptide hydrogel human amniotic mesenchymal stem cells integrin αv PI3K/AKT pathway epidermal maturation hair follicle formation growth factors EGF bFGF VEGF TGF-β angiogenesis wound re-epithelialization epidermal growth factor basic fibroblast growth factor vascular endothelial growth factor transforming growth factor beta

From the encyclopedia

Epidermal Growth Factor →

Vascular Endothelial Growth Factor →

Studysummary This study reported that the use of composite RGDmix hydrogel improved the survival and proliferation of human amniotic mesenchymal stem cells and increased growth factor expression, enhancing wound healing through the RGDSP/integrin αv/PI3K/AKT signaling pathway.

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