Prostate Cancer and Androgenic Alopecia

February 2012 in “ Expert Review of Endocrinology & Metabolism ”

Michael A. Yassa, Tarek Hijal, Philippe Giraud

androgenic alopecia prostate cancer androgens dihydrotestosterone DHT finasteride UV exposure vitamin D SRD5A2 A49T genomic studies scalp microenvironment prostate microenvironment AA PC Propecia

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Studysummary This abstract reviews the unclear link between androgenic alopecia and prostate cancer, highlighting the need for further research to determine the mechanisms connecting these two conditions.

Our plain-language summary. Not medical advice or a treatment recommendation. Consult a qualified healthcare professional before changing treatment. Full disclaimer

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Research cited in this study

19 / 19 results

research Susceptibility Variants on Chromosome 7p21.1 Suggest HDAC9 as a New Candidate Gene for Male-Pattern Baldness

51 citations , November 2011 in “British Journal of Dermatology”

This study suggests that the HDAC9 gene is a third susceptibility gene for male-pattern baldness, with significant associations found in both German and Australian samples.

research Male Pattern Baldness and the Risk of Prostate Cancer

38 citations , February 2011 in “Annals of Oncology”

This study found that early-onset androgenic alopecia is associated with a higher risk of developing prostate cancer, although it was not linked to earlier diagnosis or more aggressive tumors.

research Efficacy and Safety of Finasteride Therapy for Androgenetic Alopecia

152 citations , October 2010 in “Archives of Dermatology”

This study found that daily oral finasteride may increase hair count and improve hair appearance assessments in men with androgenetic alopecia, but it also appears to raise the risk of sexual dysfunction.

research Androgenic Alopecia Is Not Useful as an Indicator of Men at High Risk of Prostate Cancer

28 citations , June 2010 in “European Journal of Cancer”

This study found that androgenic alopecia at an early age was associated with a lower risk of prostate cancer, contrary to assumptions about androgens' role.

research Association of Androgenetic Alopecia with Metabolic Syndrome in Men: A Community-Based Survey

69 citations , April 2010 in “British Journal of Dermatology”

This study found a significant association between androgenetic alopecia and metabolic syndrome, highlighting high-density lipoprotein cholesterol as a particularly important factor.

research Male Pattern Baldness and Prostate Cancer Risk in a Population-Based Case-Control Study

29 citations , March 2010 in “Cancer epidemiology”

This study found that early-onset male pattern baldness was associated with a reduced relative risk of prostate cancer.

research Is Androgenetic Alopecia a Risk for Atherosclerosis?

38 citations , February 2009 in “Journal of The European Academy of Dermatology and Venereology”

This study found that patients with severe vertex pattern androgenetic alopecia had significantly higher carotid intima-media thickness, suggesting an increased risk of subclinical atherosclerosis compared to other alopecia patterns and healthy controls.

research 5α-Reductase Isozymes and Androgen Actions in the Prostate

93 citations , February 2009 in “Annals of the New York Academy of Sciences”

This review describes the roles of 5α-reductase isozymes in prostate development and pathology and reports no new clinical results.

research Androgens and Hair Growth

209 citations , September 2008 in “Dermatologic Therapy”

This review discusses the role of androgens in hair follicle regulation and suggests that a better understanding could enhance treatments for conditions like hirsutism and alopecia, but does not present new findings.

research Androgenic Alopecia May Have Evolved to Protect Men from Prostate Cancer by Increasing Skin Exposure to Ultraviolet Radiation

6 citations , October 2007 in “Medical Hypotheses”

This article proposes that androgenic alopecia might be an evolutionary mechanism for reducing prostate cancer risk by enhancing UV absorption, rather than being a risk factor.

research 5α-Reductase Type 2 Gene Variant Associations with Prostate Cancer Risk, Circulating Hormone Levels, and Androgenetic Alopecia

57 citations , November 2006 in “International Journal of Cancer”

This study found that the SRD5A2 A49T A variant is associated with an increased risk of prostate cancer, lower circulating 3α‐diolG levels, and a decreased risk of baldness.

research Prevalence of Male and Female Pattern Hair Loss in Maryborough

193 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

This study found that the prevalence of androgenetic alopecia increases with age among both men and women in Maryborough, Australia, with 57% of women and 73.5% of men aged 80 and over affected.

research Androgenetic Alopecia: Pathogenesis and Potential for Therapy

174 citations , November 2002 in “Expert Reviews in Molecular Medicine”

This review discusses the genetic factors contributing to androgenetic alopecia and highlights the potential for developing more effective therapies based on recent discoveries, but reports no new clinical results.

research The Biology of Hair Follicles

1113 citations , August 1999 in “The New England Journal of Medicine”

This article discusses the biologic and psychosocial significance of hair, the current limitations in hair growth drugs, and anticipates future therapies based on advancing hair follicle research.

research Risk Factors for Prostate Cancer: A Case-Control Study in Greece

127 citations , March 1999 in “International Journal of Cancer”

This study from Athens, Greece observed that urban living may increase prostate cancer risk, while early adulthood sexual activity might inversely relate to this risk.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

In male pattern hair loss, this study found that finasteride 1 mg daily significantly slowed hair loss and increased hair growth over two years compared to placebo.

Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

research Different Levels of 5α-Reductase Type I and II, Aromatase, and Androgen Receptor in Hair Follicles of Women and Men with Androgenetic Alopecia

416 citations , September 1997 in “Journal of Investigative Dermatology”

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

research Psychological Effects of Androgenetic Alopecia on Women: Comparisons with Balding Men and Female Control Subjects

222 citations , October 1993 in “Journal of The American Academy of Dermatology”

This study found that androgenetic alopecia causes significant psychological distress, particularly in women, who exhibit a more negative body image and less adaptive functioning compared to controls.

research Losing Hair, Losing Points? The Effects of Male Pattern Baldness on Social Impression Formation

68 citations , February 1990 in “Journal of Applied Social Psychology”

This study found that men with common male pattern baldness received less favorable initial social perceptions, including lower ratings of physical attractiveness, than their nonbalding counterparts.